The blaze started at 4:45 p.m. in a three story apartment complex on the 9100 block of Academy Road.
Authorities had shut down the Academy Road ramps to and from I-95, which remained closed for some of Wednesday morning.
The American Red Cross set up a shelter for the approximately 100 displaced residents at nearby Abraham Lincoln High School on Ryan Avenue.
Five people have been hospitalized due to minor injuries from the fire.